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目的探讨感染后肠易激综合征(PI-IBS)与溃疡性结肠炎( UC)缓解期病人肠黏膜细胞因子的表达,从神经-免疫机制分析肠易激综合征(IBS)与炎症性肠病(IBD)的相关性。方法 PI-IBS组病人20例,UC组病人45例,正常对照组30例,结肠镜下取直肠黏膜标本,采用免疫组化方法检测其肠黏膜细胞因子的表达情况。结果PI-IBS病人直肠IFN-γ、IL-2阳性表达高于对照组(χ2=14.012、13.931,P<0 .01) ,而与UC病人比较差异无统计学意义(χ2=2.290、2.323,P>0 .05)。PI-IBS病人直肠黏膜P物质(SP)强度均值高于对照组(t=3.722,P<0 .01) ,而与UC病人比较差异无统计学意义(t=1.643,P>0 .05)。直肠黏膜IFN-γ、IL-2阳性表达的PI-IBS病人SP强度均值高于对照组(t=2.301、2.252,P<0 .05) ,与UC病人比较差异无统计学意义(t=1.574,1.676,P>0 .05)。结论 PI-IBS与IBD之间可能存在某种相关性。
Objective To investigate the expression of intestinal mucosal cytokines in patients with remission of irritable bowel syndrome (PI-IBS) and ulcerative colitis (UC) and to analyze the relationship between irritable bowel syndrome (IBS) and inflammatory bowel Disease (IBD) relatedness. Methods Twenty patients in the PI-IBS group, 45 patients in the UC group and 30 in the normal control group were enrolled in this study. The colon mucosa was taken under colonoscopy and the expression of cytokines in the intestinal mucosa was detected by immunohistochemistry. Results The positive expression of IFN-γ and IL-2 in rectum of patients with PI-IBS was higher than that of the controls (χ2 = 14.012 and 13.931, P <0.01), but no significant difference with UC patients (χ2 = 2.290,2.323, P> 0 .05). The average value of SP in PI-IBS patients was higher than that in control group (t = 3.722, P <0.01), but no significant difference with UC patients (t = 1.643, P> 0.05) . The average SP intensity of PI-IBS patients with positive expression of IFN-γ and IL-2 in rectal mucosa was significantly higher than that in control group (t = 2.301,2.252, P0.05), but there was no significant difference with UC patients (t = 1.574 , 1.676, P> 0.05). Conclusion There may be some correlation between PI-IBS and IBD.