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敌桔双对实验动物(大鼠、小鼠和猴)有致畸作用,并有明显的剂量-反应关系和种属差异,对大鼠是强致畸物(TD_(50)为2.18mg/kg)。毒物动力学研究也提示这一点。敌枯双可抑制实验动物胚胎组织DNA和RNA合成,以及抑制人胚上腭间质细胞生长(IC_(50)为1.32×10~6mol/L)。在理论上对人有潜在的致畸。两次人群流行病学调查,均未揭示使用敌枯双地区不良妊娠结局发生率有明显增加;对生产敌枯双女工妊娠结局健康调查,也未表明敌枯双对人有明显的致畸作用。居民食用喷药3次或1次后,稻米的接触日剂量为大鼠致畸阈剂量(TD_(01)为0.22mg/kg)的1/367和1/4400。在目前还未找到有效的农药取代敌枯双情况下,在切实加强危险度管理的基础上,敌枯双可以作为农药使用。
The antagonistic effects on the experimental animals (rats, mice and monkeys) were obvious and the dose-response relationship and species differences were obvious. The antagonistic effect was strong on rats (TD_ (50) was 2.18mg / kg ). Toxicokinetic studies also suggest this. Dikuangshuang could inhibit the DNA and RNA synthesis in embryonic tissues and inhibit the growth of palatoplasty cells in human embryos (IC 50 (1.32 × 10 ~ 6mol / L)). In theory, there is potential for teratogenic. Epidemiological survey of the two populations did not reveal the use of enemy Zuobu region adverse pregnancy outcomes have significantly increased the incidence of the production of hostile drunk double pregnant women pregnancy outcome survey did not show the enemy drown double pairs of people have a significant teratogenic effect . Residents inhaled spray 3 times or 1 times, the daily exposure to rice doses of rat teratogenic threshold dose (TD_ (01) of 0.22mg / kg) 1/367 and 1/4400. Under the situation that no effective pesticide has been found to replace the enemy’s and the enemy has not yet been found, it can be used as a pesticide on the basis of effectively strengthening risk management.