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转化生长因子β具有多种生物学活性,对前列腺增生和前列腺癌上皮细胞表现为抑制,对前列腺癌和前列腺增生来源的成纤维细胞亦为抑制,TGF-β也有免疫抑制及刺激血管生长作用, 但低分化的前列腺肿瘤则不被 TGF-β所抑制,前列腺上皮细胞不仅有 TGF-β受体,也含有 TGF-β,细胞中的 TGF-β,mRNA 和 TGF-β均随病变由增生向癌变而升高,这些细胞中的 TGF-β及 TGF-β受体受雄激素的调节。
Transforming growth factor beta has a variety of biological activity, inhibition of prostate hyperplasia and prostate cancer epithelial cells, inhibition of prostate cancer and benign prostatic hyperplasia derived fibroblasts, TGF-β also has immunosuppression and stimulate vascular growth, However, poorly differentiated prostate tumors are not inhibited by TGF-β. Prostate epithelial cells not only have TGF-β receptors, but also TGF-β. TGF-β, mRNA and TGF- Carcinogenesis and increased, TGF-β and TGF-β receptors in these cells by androgen regulation.