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目的通过测定乙肝患者血浆纤维蛋白原的变化,探讨纤维蛋白原对各型乙型肝炎的诊断价值。方法应用全自动血凝仪以Clauss法分别测定50例急性肝炎,48例慢性活动性肝炎,11例重型肝炎,18例肝硬化及66例正常对照者的血浆纤维蛋白原的含量。并比较各型乙型肝炎与正常对照的纤维蛋白原的水平差异。结果急性肝炎组与对照组间纤维蛋白原的含量差异无统计学意义(P>0.05),慢性活动性肝炎、肝硬化及重型肝炎与对照组比较差异有统计学意义(P<0.01)。结论血浆纤维蛋白原检测能反映乙肝患者肝功能受损的凝血变化,对预后的判断有良好的临床应用价值。
Objective To investigate the value of fibrinogen in the diagnosis of various types of hepatitis B by measuring the changes of plasma fibrinogen in hepatitis B patients. Methods The contents of plasma fibrinogen in 50 cases of acute hepatitis, 48 cases of chronic active hepatitis, 11 cases of severe hepatitis, 18 cases of liver cirrhosis and 66 cases of normal control were measured by Clauss method with automatic coagulation analyzer. The differences of fibrinogen levels between different types of hepatitis B and normal controls were compared. Results There was no significant difference in the content of fibrinogen between acute hepatitis group and control group (P> 0.05). There was significant difference between chronic active hepatitis, cirrhosis and severe hepatitis group and control group (P <0.01). Conclusion The detection of plasma fibrinogen can reflect the change of blood coagulation in patients with hepatitis B, which has a good clinical value in judging the prognosis.