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目的检测胃动素在胃癌组织中的表达并探讨其与胃癌临床病理特征的关系。方法采用免疫组化SP法检测胃癌、癌旁及正常胃黏膜组织中胃动素蛋白的表达,对胃癌组织中胃动素蛋白的表达及其与胃癌临床病理特征之间的关系进行分析。结果胃癌组织中胃动素蛋白表达水平(1 206.43±631.67)明显高于正常胃黏膜组织(890.55±98.67)和癌旁组织(922.75±265.99),P<0.01,而癌旁组织和正常胃黏膜组织中胃动素蛋白表达水平的差异无统计学意义(P>0.05)。胃动素蛋白表达与肿瘤部位、肿瘤分化程度及淋巴结转移有关(P<0.05)。结论胃动素可能参与胃癌的发生,并与胃癌的侵袭和转移相关。
Objective To detect the expression of motilin in gastric carcinoma and to explore its relationship with the clinicopathological features of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of motilin in gastric cancer, paracancer and normal gastric mucosa tissues. The expression of motilin in gastric cancer tissue and its relationship with the clinicopathological features of gastric cancer were analyzed. Results The expression of motilin protein in gastric cancer tissue was significantly higher than that in normal gastric mucosa (890.55 ± 98.67) and adjacent non-cancerous tissues (922.75 ± 265.99, P <0.01), while paracancerous tissue and normal gastric mucosa There was no significant difference in the expression of motilin protein between the two groups (P> 0.05). Motilin expression was correlated with tumor location, tumor differentiation and lymph node metastasis (P <0.05). Conclusion Motilin may be involved in the occurrence of gastric cancer and is associated with the invasion and metastasis of gastric cancer.