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替硝唑是继甲硝唑之后开发出的新的5-硝基咪唑类衍生物之一。它通过抑制DNA,降解DNA,阻断DNA的转录而导致厌氧菌死亡,故为厌氧菌杀菌剂,且杀菌浓度仅为抑菌浓度的1倍左右。目前,对它的剂型研究已多方面展开。由于其口服吸收好。可分布于唾液、胆汁及生殖道分泌物中,已广泛应用于内科、外科、妇产科及口腔科等多种疾病。现将其主要应用研究进展及不良反应做一综述。l 临床应用研究1.1 治疗肝阿米巴病 据报道给肝阿米巴患者每日服用替硝
Tinidazole is one of the new 5-nitroimidazole derivatives developed after metronidazole. It inhibits DNA, DNA degradation, DNA transcription and lead to anaerobic death, it is anaerobic bactericides, and bactericidal concentration of only about 1 times the concentration of antibacterial. At present, its formulation research has been carried out in many ways. Because of its good oral absorption. Can be distributed in saliva, bile and reproductive tract secretions, has been widely used in internal medicine, surgery, obstetrics and gynecology and other diseases. Now the main application of research progress and adverse reactions to do a review. l clinical research 1.1 treatment of hepatic amoebiasis reported to patients with liver amebiasin for daily use