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胃泌素瘤是一种胰岛非β细胞瘤,首先由Zollinger和—Ellison报告,故名Zollinger,—Ellison综合征。肿瘤分泌大量胃泌素而引起高胃酸分泌,临床上以暴发性、多发性、异位性、顽固性和复发性消化性溃疡为特征性表现,常伴有腹泻和吸收不良。2/3以上的病例肿瘤为多发性,恶性者占60%,良性占30%,10%仅为胰岛增生。少数肿瘤发生于胰外,主要在十二指肠。近年来由于H_2受体拮抗剂,及H~+—K~+ATP酶抑制剂—洛塞克(Losec,Omeprazole)的问世,几乎每一个病例均可通过内科方法长期控制高胃酸分泌,从而减少了全胃切除的必要;消化性溃疡可药物控制,病人生存期取决于肿瘤的生长和转移,因而肿瘤定位极为重要;随着影象和放免技术的发展,目前有可能进行肿瘤精确定
Gastrinomas are non-beta cell tumors of the islet, first reported by Zollinger and -Ellison, hence the name Zollinger, -Ellison syndrome. The tumor secretes a lot of gastrin and causes high gastric acid secretion. Clinically, it is characterized by fulminant, multiple, atopic, refractory and recurrent peptic ulcers, often accompanied by diarrhea and malabsorption. In more than 2/3 cases, the tumors were multiple, 60% were malignant, 30% were benign, and 10% were only islet hyperplasia. A small number of tumors occur outside the pancreas, mainly in the duodenum. In recent years, due to the advent of H2 receptor antagonists and Loce, Omeprazole, an H~+-K~+ ATPase inhibitor, high gastric acid secretion can be controlled in almost every case by medical methods, thereby reducing The need for total gastrectomy; peptic ulcer drug control, patient survival depends on the growth and metastasis of the tumor, and thus the location of the tumor is extremely important; with the development of imaging and radioimmunoassay, it is currently possible to determine the tumor fine