带有N-H、O-H基团的酸性药物,包括巴比土类、羧酸、酚、磺酰胺、甾体激素、生物碱以及嘌呤、嘧啶和黄嘌呤类的含氮杂环药物在气液层析时,由于分子间存在着范德华引力和氢键,表现出不同程度的极性,在固定相上容易被吸附,常导致被测物质的丢失、层析柱被污染、在谱图上出现严重的拖尾现象、保留时间亦较长。同时这些药物需要较高的温度才能气化,而较高的温度又可能使之分解。由此,应用气液层析法对这些药物的鉴定和定量分析变得十 Acidic drugs with NH, OH groups, including heterocyclic compounds such as barbiturates, carboxylic acids, phenols, sulfonamides, steroid hormones, alkaloids and purine, pyrimidine and xanthine nitrogen containing heterocyclic drugs in gas-liquid chromatography , Due to van der Waals forces and hydrogen bonds between molecules, they show different degrees of polarity and are easily adsorbed on the stationary phase, often resulting in the loss of the measured substance, the chromatographic column being contaminated, and serious chromatograms Trailing phenomenon, retention time is longer. At the same time, these drugs require higher temperatures to vaporize, and higher temperatures can cause them to decompose. Thus, the identification and quantitative analysis of these drugs using gas-liquid chromatography becomes ten