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NPR1蛋白是水杨酸信号和系统获得性抗性的转录调节因子,它的功能受蛋白质降解酶体CUL3-E3的控制。植物的发育主要受生长素信号通路的控制,生长素反应因子(ARF)参与生长素信号转导转录调控。植物转录因子NPR1和ARF8分别在蛋白质降解酶体CUL3-E3与CUL1-E3控制下,调控抗病防卫与生长发育。烟草TTG2促进ARF8从细胞质向细胞核转运及其转录调控作用,因此促进生长发育;相反,TTG2把NPR1扣留在细胞质,阻止它对防卫反应基因的转录调控作用,从而抑制抗病性。TTG2与NPR1或ARF8并不直接互作,说明存在协助因子。
The NPR1 protein is a transcriptional regulator of salicylic acid signaling and system-acquired resistance and its function is controlled by the protein-degrading enzyme CUL3-E3. Plant development is mainly controlled by the auxin signaling pathway, and auxin response factor (ARF) is involved in auxin signal transduction and transcription regulation. Plant transcription factors NPR1 and ARF8, respectively, under the control of proteasomes CUL3-E3 and CUL1-E3, regulate disease-resistant defense and growth. Tobacco TTG2 promotes ARF8 transport from the cytoplasm to the nucleus and its transcriptional regulation, thus promoting growth and development; on the contrary, TTG2 retains NPR1 in the cytoplasm and prevents its transcriptional regulatory role in defensive response genes, thereby inhibiting disease resistance. TTG2 does not interact directly with NPR1 or ARF8, indicating the presence of a cofactor.