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目的：探讨正常及妊高征孕妇血浆ＣＧＲＰ 水平变化及其ＣＧＲＰ 在妊高征发病中的作用。方法：采用放射免疫分析法测定了妊高征妇女６８ 例、正常孕妇８７ 例及正常非孕妇女１０ 例的血浆ＣＧＲＰ 水平。结果：正常孕妇血浆ＣＧＲＰ 水平早期（１１１ ．４０ ±５７ ．０６ｎｇ／Ｌ） 与正常非孕妇对照（９０ ．８６ ±５８ ．１４ｎｇ／Ｌ） 无明显差异， 随着孕期进展逐渐升高（ 中孕２１３ ．９６ ±１０８ ．６７ｎｇ／Ｌ， 晚孕３２３ ．３９ ±１３１ ．９４ｎｇ／Ｌ） ； 妊高征患者血浆ＣＧＲＰ 水平轻度（３２９ ．８９ ±１１４ ．４４ｎｇ／Ｌ） 与正常晚孕对照无差异，随着病情加重逐渐降低（ 中度２５５ ．４４ ±１２１ ．５３ｎｇ／Ｌ， 重度１７４ ．１１ ±８４ ．７５ｎｇ／Ｌ） ； 血浆ＣＧＲＰ 水平与平均动脉压、血清离子钙水平间无明显直线相关关系。结论：ＣＧＲＰ 对妊娠期血压稳定具有重要调节作用， 其血浆含量降低可能是引起妊娠高血压的因素之一
Objective: To investigate the changes of plasma CGRP levels and the role of CGRP in the pathogenesis of PIH in normal and PIH pregnant women. Methods: Plasma CGRP levels were measured by radioimmunoassay in 68 pregnant women with PIH, 87 normal pregnant women and 10 normal pregnant women. Results: There was no significant difference in plasma CGRP levels between normal pregnant women (111 .40 ± 57 .06ng / L) and normal controls (90.86 ± 58.14ng / L), with the progress of pregnancy increasing .96 ± 108.67ng / L, 323.39 ± 131.94ng / L in the third trimester of pregnancy). The level of plasma CGRP in patients with PIH was mild (329.89 ± 114.44ng / L) There was no significant linear correlation between plasma CGRP level and mean arterial pressure and serum ionized calcium level as the disease progressed. (Moderate 255.44 ± 121.53ng / L, severe 174.11 ± 84.75ng / L). CONCLUSION: CGRP plays an important role in the regulation of blood pressure during pregnancy. Decreased plasma levels may be one of the factors that cause pregnancy-induced hypertension