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氯喹(Chloroquinoline)为4-氨基喹啉类衍生物,其磷酸盐是广泛应用于临床的人工抗疟药。工作中发现口服过量氯喹致死的案件较为常见。在生物样品中检验氯喹,以往多采用TLC、UV或化学反应等方法。笔者在此介绍了分析生物样品中氯喹的GC、GC/MS方法。
Chloroquinoline is a 4-aminoquinoline derivative whose phosphate is a widely used artificial anti-malarial drug in the clinic. In the work found orally overdose of chloroquine lethal cases are more common. Chloroquine is tested in biological samples. In the past, TLC, UV or chemical reaction methods were used. Here I describe the analysis of biological samples of chloroquine by GC, GC / MS methods.