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病毒性心肌炎以小儿多见 ,柯萨奇B组病毒 (CoxB )是主要病原。IL 6、IL 8和TNF α是免疫和炎症的重要调节因子。我们采用ELISA测定血清中IL 6、IL 8和TNF α三种因子 ,观察到在病毒性心肌炎的早期 ,IL 6、IL 8和TNF α水平较正常儿水平均显著增高 ,且与临床表现、心电图改变、心肌酶的升高是一致的。这三种因子水平的升高可以作为病毒性心肌炎急性阶段的一个重要指标 ,4周后病情进入恢复期 ,IL 6和TNF α水平已降至正常而IL 8仍显著高于正常 ,说明疾病仍未治愈。因此我们认为IL 8恢复至正常可以作为判断病毒性心肌炎治愈及预后判断的主要指标。
Viral myocarditis is more common in children, Coxsackie B virus (CoxB) is the main pathogen. IL 6, IL 8 and TNF α are important regulators of immunity and inflammation. We measured the levels of IL-6, IL-8 and TNF-alpha in serum by ELISA and found that the levels of IL-6, IL-8 and TNF-alpha were significantly higher than those of normal children in the early stage of viral myocarditis. Change, the increase of myocardial enzymes is consistent. Elevated levels of these three factors can be used as an important indicator of the acute phase of viral myocarditis. After 4 weeks, the condition has entered a recovery phase. Levels of IL-6 and TNF-α have dropped to normal while IL-8 is still significantly higher than normal, indicating that the disease is still Not cured. Therefore, we believe that the return of IL 8 to normal can be used as a predictor of cure and prognosis of viral myocarditis.