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目的:探讨胃癌D2根治术后腹腔引流液的癌胚抗原(CEA)水平变化对病情评估及预后判断的临床价值。方法:采用化学发光免疫分析法检测68例胃癌患者术d1、d3腹腔引流液CEA浓度,分析其与肿瘤浸润深度、淋巴结转移及病理分期的关系。结果:胃癌D2根治术后腹腔引流液CEA水平随肿瘤突破黏膜层、淋巴结转移、病理分期增加而上升(P<0.05),在T1、N0及Ⅰ、Ⅱ期患者中较低;当肿瘤突破黏膜层和(或)淋巴结转移后明显升高,P<0.05。结论:检测胃癌D2根治术后腹腔引流液CEA有助于病情估计及预后判断。
Objective: To investigate the clinical value of the change of carcinoembryonic antigen (CEA) in the peritoneal drainage fluid after D2 radical gastrectomy for the evaluation of disease and prognosis. Methods: The chemiluminescent immunoassay was used to detect CEA concentrations in d1 and d3 peritoneal drainage fluid of 68 patients with gastric cancer. The relationship between them and tumor invasion depth, lymph node metastasis and pathological stage was analyzed. Results: The level of CEA in peritoneal drainage fluid after D2 radical operation of gastric cancer increased with the breakthrough of mucosa, lymph node metastasis and pathological stage (P <0.05), but lower in T1, N0 and stage Ⅰ, Ⅱ patients. When tumor breakthrough mucosa Layer and / or lymph node metastasis was significantly increased, P <0.05. Conclusion: The detection of CEA in peritoneal drainage fluid after radical resection of D2 gastric cancer is helpful to estimate the disease and prognosis.