我们从1979年11月至1985年9月,根据筛选常染色体异常综合征的临床指征:先天畸型、智力低下和皮纹脊图型异常,以及性染色体异常的临床特征,对33例患者进行了细胞遗传学分析,染色体异常的发生率为18%,4例常染色体异常,2例性染色体异常.对4例常染色体异常病人进行5年的染色体分析的随访,发现患者体内异常细胞系的比例随年龄的增长而逐渐下降. From November 1979 to September 1985, 33 patients underwent screening based on clinical indications for screening for atypia syndrome: congenital malformations, mental retardation and dermatoglyphic anomalies, and clinical features of sex chromosome abnormalities According to cytogenetic analysis, the incidence of chromosomal abnormalities was 18%, 4 cases of autosomal abnormalities and 2 cases of chromosomal abnormalities.All 4 cases of autosomal abnormalities were followed up for 5 years and found that abnormal cell lines The proportion decreases with age.