高血压是一种以平滑肌细胞增生为主要病变的疾病。近来的研究结果表明:高血压时,血管平滑肌细胞处于“合成状态”,细胞可以分裂、增殖,并有迁移性,此时血管平滑肌细胞内myc mRNA增加了14％～100％。汤健等也发现自发性高血压大鼠血管平滑肌细胞、心肌和肝脏中myc基因的转录水平明显高于wky大鼠。除此之外,sis基因表达亦高于wky大鼠,而fos基因的表达则高出wky大鼠5～8倍。由此可见,myc、fos、sis癌基因的激活可能引起平滑肌细胞增殖和肥厚,进而导致高血压发生。 Hypertension is a disorder characterized by smooth muscle cell proliferation. Recent studies have shown that: In hypertension, vascular smooth muscle cells in a “synthetic state”, the cells can divide, proliferate, and migrate, then myc mRNA increased by 14% to 100% in vascular smooth muscle cells. Tang Jian also found that spontaneous hypertensive rats vascular smooth muscle cells, myocardial and liver myc gene transcription was significantly higher than wky rats. In addition, sis gene expression is also higher than wky rats, while fos gene expression is 5 to 8 times higher than wky rats. Thus, myc, fos, sis oncogene activation may cause smooth muscle cell proliferation and hypertrophy, which led to hypertension.