细胞凋亡是基因控制的程序性死亡,与口腔黏膜癌变密切相关。为进一步探讨程序性细胞死亡调控与口腔黏膜癌变的关系,进而了解口腔黏膜癌变的发病机制,探索预防和治疗口腔黏膜癌变的手段,研究程序性细胞死亡相关基因是必要的。下面就与口腔黏膜癌变相关的程序性细胞死亡调控基因的研究进展作一综述。 Apoptosis is a gene-controlled programmed death that is closely related to carcinogenesis of oral mucosa. In order to further explore the relationship between the regulation of programmed cell death and carcinogenesis of oral mucosa, and then to understand the pathogenesis of oral mucosal carcinogenesis and explore ways to prevent and treat oral mucosal carcinogenesis, it is necessary to study the gene related to apoptosis. The following is a review on the progress of programmed cell death regulatory genes associated with oral mucosal carcinogenesis.