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前蛋白转化酶枯草溶菌素-9(PCSK9)能通过调节细胞膜表面低密度脂蛋白受体,影响血脂代谢,并参与动脉粥样硬化过程。近年来研究表明,PCSK9基因多态性可能与血脂异常及心血管疾病有关。现就PCSK9基因多态性与心血管疾病的研究进展做一综述。
The pro-protein convertase subtilisin-9 (PCSK9) can affect the metabolism of lipids and regulate the process of atherosclerosis by regulating the low density lipoprotein receptor on the surface of cell membrane. In recent years, studies have shown that, PCSK9 gene polymorphisms may be related to dyslipidemia and cardiovascular disease. Now the research progress of PCSK9 gene polymorphism and cardiovascular disease are reviewed.