论文部分内容阅读
小细胞肺癌(SCLC)脑转移的发病率约20～25%。预防性脑部照射(PCI)可使其发病率从22%下降至6%。作者报导225例SCLC在首次化疗后有39例出现脑转移。全部39例有脑转移的病人,使用大剂量地塞米松治疗,其中32例采用了PCI。这些病人接受5次照射(中心平面剂量20Gy);并选择地对化疗失败的病人进行胸部照射,总剂量40～55Gy,以控制局部病变。结果,8例(20%)神经系统症状完全缓解,10
The incidence of brain metastases in small cell lung cancer (SCLC) is about 20-25%. Preventive brain irradiation (PCI) can reduce its incidence from 22% to 6%. The authors reported that brain metastases occurred in 39 of 225 SCLC patients after the first chemotherapy. All 39 patients with brain metastases were treated with high-dose dexamethasone, 32 of whom used PCI. These patients received 5 exposures (central plane dose of 20 Gy); and patients who failed chemotherapy were selected for chest irradiation with a total dose of 40-55 Gy to control local lesions. As a result, 8 cases (20%) had complete relief of nervous system symptoms, 10