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目的探讨保乳手术加术中放疗在早期乳腺癌治疗中的美容效果及临床安全性。方法2008年12月-2009年10月对40例早期乳腺癌患者行保乳手术联合电子线术中放疗。采用Mobetron1000移动式电子束术中放疗系统,靶区为可见的肿瘤及其周边2cm、下方1cm范围内的正常组织,中位剂量15Gy。观察术后近期治疗效果、美容效果及不良反应。结果全组中位随访190d,未见局部复发,美容效果优或良占95%,I级放射性肺损伤发生率12.5%,局部乳腺轻微纤维化发生率5%,1例患者术后出现切口感染。结论术中放疗未明显增加保乳术的并发症及手术时间;保乳手术联合术中放疗近期疗效及美容效果良好,不良反应较轻。
Objective To investigate the cosmetic effect and clinical safety of breast-conserving surgery combined with intraoperative radiotherapy in the treatment of early breast cancer. Methods From December 2008 to October 2009, 40 patients with early breast cancer underwent breast conserving surgery combined with electrosurgical radiotherapy. Using Mobetron1000 mobile electron beam surgery radiotherapy system, the target area is visible tumor and the surrounding 2cm, below the normal range of 1cm, the median dose of 15Gy. To observe the short-term postoperative treatment, cosmetic effects and adverse reactions. Results All the patients were followed up for a median of 190 days. No local recurrence was found. The cosmetic effect was excellent or 95%. The incidence of grade I radiation lung injury was 12.5%. The incidence of local breast fibrosis was 5%. Incision infection occurred in 1 patient . Conclusion Intraoperative radiotherapy did not significantly increase the complications and operation time of breast-conserving surgery; breast-conserving surgery combined with intra-operative radiotherapy has short-term curative effect and good cosmetic effect with mild adverse reactions.