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目的检测一种新颖的褪黑素受体激动剂Neu-P11与褪黑素对大鼠物体识别记忆的影响。方法大鼠物体识别测试包括两个阶段即4 min的训练期和3 min的测试期。在上午或下午于训练前2 h注射Neu-P11(50 mg/kg)、褪黑素(50 mg/kg)或溶媒。训练结束后4 h或24 h,分别检测大鼠的短时程与长时程记忆保持。记录并分析各组大鼠在训练期的总探究时间与测试期的辨别指数。结果在短时程记忆及长时程记忆测试中,无论上午或下午给药,各组大鼠在训练期间的总探究时间组间差异无显著性,且Neu-P11处理组大鼠其辨别指数均显著性高于溶媒组;褪黑素处理组大鼠仅在下午给药时其辨别指数显著性高于溶媒组。结论 Neu-P11与褪黑素均能增强大鼠物体识别记忆,且Neu-P11的效应是给药时间非依赖的。
Objective To detect the effect of a novel melatonin receptor agonist Neu-P11 and melatonin on rat object recognition memory. Methods The rat object recognition test consisted of two phases, a 4-min training session and a 3-min test session. Neu-P11 (50 mg / kg), melatonin (50 mg / kg) or vehicle were injected in the morning or afternoon at 2 h prior to training. After training for 4 h or 24 h, the short-term and long-term memory retention in rats were measured. Record and analyze the discrimination index of the total exploration time and test period of rats in training group. Results In the short-term memory and long-term memory test, regardless of the morning or afternoon administration, there was no significant difference between the groups in the total duration of the study during the training period, and the discrimination index of Neu-P11-treated rats Were significantly higher than the vehicle group; melatonin treatment group only when the afternoon administration of its index was significantly higher than the vehicle group. Conclusion Both Neu-P11 and melatonin enhance the memory of rat object recognition, and the effect of Neu-P11 is time-independent.