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目的:评价咪达唑仑经鼻喷雾用于幼儿术前焦虑的临床疗效。方法:80例拟在全麻下行择期手术的幼儿(年龄1~3岁),美国麻醉医师协会(ASA)生理状态评分Ⅰ~Ⅱ级,随机分为咪达唑仑组和生理盐水组各40例,进入手术室前5 min采用MAD Nasal~(TM)经鼻黏膜喷雾给药装置分别给予咪达唑仑(5 mg/m L)和生理盐水0.04 m L/kg。观察并记录患儿与家长分离时的镇静评分(G评分)、麻醉诱导时的面罩接受程度评分(S评分)、术毕拔管时间、麻醉苏醒期躁动评分(EA评分)及不良反应。结果:咪达唑仑组G评分、S评分均高于生理盐水组(P<0.01),EA评分低于生理盐水组(P<0.01)。两组术毕拔管时间比较差异无统计学意义(P>0.05)。两组均未见术前用药或麻醉相关不良反应。结论:咪达唑仑经鼻喷雾可有效用于幼儿术前焦虑。
Objective: To evaluate the clinical efficacy of midazolam nasal spray for preoperative anxiety in children. Methods: Totally 80 children (aged 1 to 3 years) undergoing elective surgery under general anesthesia and 1 to 2 grades of ASA physiological status were randomly divided into midazolam group and normal saline group For example, midazolam (5 mg / m L) and saline (0.04 m L / kg) were given to the nasal mucosa by MAD nasal TM 5 min before entering the operating room. The sedation score (G score), the mask acceptance score (S score), the time of extubation, the agitation and recovery agitation score (EA score) and the adverse reactions were observed and recorded when the children were separated from their parents. Results: The scores of G and S in midazolam group were higher than that of saline group (P <0.01), and the scores of EA were lower than those of saline group (P <0.01). There was no significant difference in extubation time between the two groups (P> 0.05). No preoperative or narcotic-related adverse events were seen in either group. Conclusion: Midazolam nasal spray can be effectively used for preoperative anxiety in children.