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1988年至1992年间曾对64例DukesB、C和A3期直肠癌患者进行了术前术后清栓酶导管升压热疗.每次0.5单位、每日一次,术前一疗程,术后两疗程:每疗程15至20天,停3至5天重复另一疗程:并随机选择同时期、情况基本相同和未进行术前术后化疗和清栓酶治疗的直肠癌患者64例作为对照组,术后随访2至5年。术前术后清栓酶导管升压热疗组术后局部复发率为14%、远处转移率11%;而对照组术后局部复发率为27%、远处转移率为25%,两者皆有显著差异(P<0.05)。升压、热疗使清栓酶的活性作用提高10至30倍。因此.作者认为对DukesB、C和A3直肠癌病人、在术前术后应进行清栓酶导管升压热疗,以减少术后局部复发和远处转移。
Between 1998 and 1992, 64 patients with Dukes B, C and A3 colorectal cancer were treated with preoperative and postoperative thrombectomy catheter hyperthermia. 0.5 units per day, once daily, one course before surgery, two courses after surgery: 15 to 20 days per course of treatment, 3 to 5 days rest for another course of treatment: randomly selected at the same time, the conditions are basically the same and not performed 64 patients with rectal cancer who underwent preoperative and postoperative chemotherapy and erythromycin administration were used as controls and were followed up for 2 to 5 years. The local recurrence rate was 14% and the distant metastasis rate was 11% in the hyperthermia group before and after surgery. The rate of local recurrence after surgery was 27% in the control group, and the distant metastasis rate was 25%. All had significant differences (P<0.05). Boosting and hyperthermia increase the activity of the hydratase by 10 to 30 times. therefore. The authors believe that in patients with Dukes B, C, and A3 rectal cancer, preoperative and postoperative thrombolytic catheter hyperthermia should be performed to reduce postoperative local recurrence and distant metastasis.