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目的:比较BACTEC-MGIT960全自动分枝杆菌快速药敏与罗氏比例法药敏检测方法的一致性。方法:平行检测住院患者分枝杆菌临床分离株245株的利福平(RFP)、异烟肼(INH)、链霉素(SM)、乙胺丁醇(EMB)的药物敏感性。结果:经对比检测,BACT-MGIT960全自动分枝杆菌药敏测定可在4~13 d内检测RFP,INH,SM,EMB的药物敏感性,平均7.8d。与罗氏比例法药敏的符合率分别达到98.78%,97.55%,96.73%,96.73%。平均符合率为97.45%。结论:BACTEC-MGIT 960分枝杆菌液体药敏系统,可快速准确获得药敏检测结果,尤其适用于临床分离株的快速药敏筛检。
OBJECTIVE: To compare the consistency of the drug susceptibility testing method of BACTEC-MGIT960 rapid drug sensitivity with Roche proportion method. Methods: The susceptibility of 245 clinical isolates of in-hospital patients to rifampicin (RFP), isoniazid (INH), streptomycin (SM) and ethambutol (EMB) was tested in parallel. Results: The drug sensitivity of BACT-MGIT960 mycobacterium tuberculosis was detected within 4 to 13 days after the contrast test, with an average of 7.8 days. The coincidence rate with Roche proportion method reached 98.78%, 97.55%, 96.73% and 96.73% respectively. The average coincidence rate was 97.45%. Conclusion: The BACTEC-MGIT 960 Mycobacterium liquid drug sensitivity system can rapidly and accurately obtain the drug susceptibility test results, and is especially suitable for rapid drug sensitivity screening of clinical isolates.