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采用高压液相色谱仪,对4-差向土霉素含量在土霉素发酵、提炼过程中的变化进行了系统考察研究,查明了4-差向土霉素在整个产生过程不同工序的产生情况。明确4-差土霉素在整个生产过程不同中间体中的变化趋势,确定了过滤预处理过程为4-差土霉素增幅最明显的工序,是整个生产系统中的关键影响工序。
The use of high pressure liquid chromatography, the oxytetracycline content of 4-oxytetracycline fermentation, the process of refining changes in a systematic study to identify the 4-poor oxytetracycline in the entire production process of different processes Produce the situation. The trend of 4-terramycin in different intermediates in the whole production process was clarified. The process of filtering pretreatment, which was the most obvious increase of 4-terramycin, was confirmed as the key influence process in the whole production system.