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目的：研究益气化瘀汤对大鼠慢性肾炎的药理作甩。方法：建立大鼠阿霉素肾炎、血清白蛋白肾炎模 型及急性血瘀模型，应用生化方法观察益气化瘀汤对大鼠尿蛋白、血清肌酐(Cr)和尿素氮(BUN)、血清总蛋白 (TP)、血清白蛋白(ALB)、血清球蛋白(GLB)、ALB/GLB 比值、血液流变学的影响。结果：益气化瘀汤高(24g/kg)、 低(12g/kg)剂量组与模型组比较，可降低尿蛋白、Cr 和 BUN 的含量，增加血清 TP 及 ALB 的含量，提高 ALB/GLB 的比值，降低全血黏度、血浆黏度、红细胞压积、血沉、纤维蛋白和电泳时间(P＜0． 05，P＜0． 01) 。结论：益气化瘀 汤对慢性肾炎模型大鼠有治疗作用。
Objective: To study the pharmacological effects of Yiqi Huayu Decoction on chronic nephritis in rats. METHODS: Rat adriamycin nephritis, serum albumin nephritis model and acute blood stasis model were established. The uremic protein, serum creatinine (Cr), urea nitrogen (BUN) and total serum of rats were observed by biochemical method. Protein (TP), serum albumin (ALB), serum globulin (GLB), ALB/GLB ratio, and hemorheological effects. Results: Compared with the model group, the Yiqi Huayu Decoction high (24g/kg), low (12g/kg) dose group can reduce the content of urinary protein, Cr and BUN, increase the content of serum TP and ALB, increase the ALB/GLB The ratio of blood viscosity, plasma viscosity, hematocrit, ESR, fibrin and electrophoresis time (P<0.05, P<0.01). Conclusion: Yiqi Huayu Decoction can treat chronic nephritis rats.