越来越多研究表明DNA甲基化状态异常尤其是抑癌基因的高甲基化失表达在白血病的发生发展、诊断、检测微小残留病(minimal residual disease,MRD)、预测病情以及指导治疗方面都有重要作用[1]。近年来DNA甲基化谱研究的进展以及尝试利用去甲基化药物辅助治疗白血病越来越引人注目 More and more studies have shown that DNA methylation abnormality, especially tumor suppressor gene hypermethylation loss of expression in the development of leukemia, diagnosis, detection of minimal residual disease (MRD), predict the condition and guide the treatment Important role [1]. In recent years, advances in DNA methylation profiling and attempts to use demethylation drugs to aid the treatment of leukemia have drawn increasing attention