论文部分内容阅读
母亲作为仅单倍型相同的骨髓移植(BMT)供者,文献中尚未见系统报道。作者对一组缺乏HLA相合同胞骨髓供者的晚期白血病患儿接受母体BMT病例进行回顾性总结。 1987年8月～1990年11月19例患儿接受母亲单倍型相同的BMT(研究组),年龄1～21岁。其中AML复发9例,ALL复发6例,CML幼稚期4例。以28例同期接受HLA抗原相合同胞骨髓患儿作为对照组。对照组年龄1～20岁,其中AML复发10例,ALL复发17例,CML幼稚期1例。研究组预处理方案均采用BU+CY方案;对照组采用BU+CY14例、BU+CY+VP5例,CY+TBI 9例。GVHD预防研究组均采用MTX+CsA;对照组采用MTX+CsA15例、MTX9例、csA3例。
As a donor of bone marrow transplantation (BMT) with the same haplotype only, no literature has been reported in the literature. The authors retrospectively reviewed maternal BMT cases in a group of children with advanced leukemia who lack HLA-identical sibling myeloid donors. From August 1987 to November 1990, 19 children underwent the same haplotype BMT (study group), aged 1 to 21 years old. There were 9 cases of AML recurrence, 6 cases of ALL recurrence and 4 cases of CML naive. Twenty-eight children with HLA-matched matched sibling marrow were used as control group. Control group of 1 to 20 years of age, including 10 cases of AML relapse, ALL relapsed in 17 cases, CML naive in 1 case. BU + CY regimen was used in the study group. In the control group, 14 cases were BU + CY, 5 cases were BU + CY + VP and 9 cases were CY + TBI. GVHD prevention study group were used MTX + CsA; control group using MTX + CsA15 cases, MTX9 cases, csA3 cases.