目的分析伴智能障碍的脑白质疏松症(LA)患者的相关危险因素。方法 207例LA患者分为伴有智能障碍组和无智能障碍组,对患者的性别、年龄、高血压病史、糖尿病史、冠心病史及既往脑梗死病史等进行相关因素分析和Logistic回归分析。结果两组年龄、高血压病史、糖尿病史、既往脑梗死病史和LA的严重程度均有显著差异。多因素回归分析最终入选模型的变量是年龄、高血压病史、既往脑梗死病史和重度LA。结论高龄、高血压病史、既往脑梗死病史和重度LA,对LA是否伴智能障碍有独立的提示作用。 Objective To analyze the risk factors associated with mental retardation in patients with leukoaraiosis (LA). Methods A total of 207 patients with LA were divided into two groups according to their gender, age, history of hypertension, history of diabetes mellitus, history of coronary heart disease and previous cerebral infarction. Logistic regression analysis was performed. Results There were significant differences in age, history of hypertension, history of diabetes mellitus, history of previous cerebral infarction and severity of LA. Multivariate regression analysis The variables that were ultimately enrolled in the model were age, history of hypertension, previous history of cerebral infarction, and severe LA. Conclusions The elderly, the history of hypertension, the history of previous cerebral infarction and the severe LA have an independent suggestive effect on LA with or without mental retardation.