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片剂口服进入肠胃后,先崩解成颗粒,颗粒再崩解成细粉,细粉,颗粒在胃肠中必须溶解后才能被吸收和产生作用。低取代羟丙基纤维素(LS-HPC)是一种中性的、对人体无害的纤维素衍生物,与制剂中的药物和其它辅料不起任何化学作用,具有加速片剂崩解和溶出的功能。 我们应用LS-HPC对三个品种进行处方改进,崩解时限和溶出度均收到良好的效果。 1 设备及材料 LB-812A型六管崩解仪,上海黄海药检仪器厂;RC-3型药物溶出度测定仪,天津
Tablets orally enter the stomach, the first collapse into particles, the particles break down into fine powder, fine powder, particles in the gastrointestinal must be dissolved before they can be absorbed and the role. Low-substituted hydroxypropylcellulose (LS-HPC) is a neutral, harmless, cellulose derivative that does not chemically interact with the drugs and other excipients in the formulation, accelerates the disintegration of the tablet and Dissolution function. We applied LS-HPC to the three varieties to improve the prescription, disintegration time and dissolution have received good results. 1 equipment and materials LB-812A six-tube disintegrator, Shanghai Huanghai drug testing equipment factory; RC-3 drug dissolution tester, Tianjin