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1955年,印度新德里大规模爆发流行的急性肝炎,于1980年被Wong等证实为经肠道传播的非甲非乙型肝炎[HNANB]。各国学者相继对该病进行了大量研究,经粪——口传播的非甲非乙型肝炎患者的粪便中,通过免疫电镜(IEM)检测到27～34nm的病毒颗粒;用病人的粪便感染狨猴等灵长类动物的实验了获得了成功。1989年,Reyes等应用分子克隆技术,获得了本病毒的基因克隆;并在同年9月东京国际肝炎学术会议上,将HNANB正式命名为HE,其病原体相应地被称为HEV。
In 1955, the massive outbreak of acute hepatitis in New Delhi, India, was confirmed as enterally transmitted non-A, non-B hepatitis [HNANB] by Wong et al. In 1980. Researchers from all over the world have carried out a large number of studies on this disease, and 27-34 nm of virus particles have been detected by immunoelectron microscopy (IEM) in excrement of fecal-oral non-A non-B hepatitis patients; Monkey and other primate experiments have been successful. In 1989, Reyes and other molecular cloning techniques, access to the virus gene cloning; and in September the same year Tokyo International Hepatitis Conference, HNANB formally named HE, the corresponding pathogen is called HEV.