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Bernstein等(1976)测定渗出性中耳炎中耳渗液中前列腺素(PG)E及F含量增多。Jung等(1980)于栗鼠中耳注射PGE_2,结果乳酸脱氢酶、酸性及碱性磷酸酶活性增强,钙及蛋白含量增加。非甾类抗炎药可抑制机体内前列腺素合成,为证实非甾类抗炎药对渗出性中耳炎的治疗效果作者进行了以下研究。采用直接放射免疫法测定渗出性中耳炎患儿13例19耳中耳渗液内PGE_2含量,结果:12耳含量小于1。0ng/ml;
Bernstein et al (1976) measured exudative otitis media exudate prostaglandin (PG) E and F increased. Jung et al. (1980) injected PGE 2 in the middle ear of chinchilla, resulting in increased lactate dehydrogenase, acid and alkaline phosphatase activity, and increased calcium and protein content. Non-steroidal anti-inflammatory drugs can inhibit the body’s prostaglandin synthesis, to confirm the non-steroidal anti-inflammatory drugs on the treatment of exudative otitis media the author of the following studies. The content of PGE_2 in 13 cases of middle ear effusion of exudative otitis media was measured by direct radioimmunoassay. Results: The content of 12 ears was less than 1.0ng / ml.