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目的探讨CD_(44V8-V10)在肾细胞癌中的表达及其临床意义。方法采用逆转录-多聚酶链式反应技术检测22例原发性肾细胞癌及癌周正常肾组织CD_(44V8-V10) mRNA的表达。结果 CD_(44V8-V10) mRNA在肾癌中的表达率为45.5%(10/22),而癌周正常肾组织无表达;有肾周浸润或淋巴结转移者的表达阳性率明显高于无浸润转移者(P<0.01)。结论 CD_(44V8-V10)与原发性肾癌的浸润转移表型有关。
Objective To investigate the expression of CD44V8-V10 in renal cell carcinoma and its clinical significance. Methods The expression of CD44V8-V10 mRNA in 22 cases of primary renal cell carcinoma and normal pericancerous tissue was detected by reverse transcription polymerase chain reaction (RT-PCR). Results The positive rate of CD44V8-V10 mRNA in renal cell carcinoma was 45.5% (10/22), but not in normal pericancerous tissue. The positive rate of CD44v8-V10 mRNA in renal cell carcinoma was significantly higher than that in non-invasive Transfer (P <0.01). Conclusion CD44V8-V10 is associated with the infiltration and metastasis of primary renal cell carcinoma.