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目的:探讨冠心病患者血清基质金属蛋白酶-2(MMP-2)的表达水平及与冠状动脉内径狭窄程度的相关关系。方法:通过ELISA法检测冠心病患者(n=24)和正常对照组(n=25)血清MMP-2水平,并分析冠心病患者MMP-2水平与冠状动脉内径狭窄程度的相关关系。结果:冠心病患者和健康对照组血清MMP-2表达水平依次为(48.92±14.86)ng/mL和(25.77±8.82)ng/mL,差异具有显著性(t=6.663,P=0.001);冠心病患者的MMP-2水平与冠状动脉内径狭窄程度之间存在明显相关关系(P<0.01)。结论:冠心病患者血清的MMP-2水平有明显的升高,并且MMP-2水平与冠状动脉内径狭窄程度关系密切,可能参与了冠心病的发生发展过程。
Objective: To investigate the relationship between the expression of matrix metalloproteinase-2 (MMP-2) and the degree of stenosis of coronary artery in patients with coronary heart disease. Methods: Serum MMP-2 levels in patients with coronary heart disease (n = 24) and normal controls (n = 25) were determined by ELISA. The correlation between MMP-2 and the degree of coronary artery stenosis was analyzed. Results: The serum levels of MMP-2 in patients with coronary heart disease and healthy controls were (48.92 ± 14.86) ng / mL and (25.77 ± 8.82) ng / mL respectively, with significant difference (t = 6.663, P = 0.001) There was a significant correlation between the level of MMP-2 and the degree of stenosis of coronary artery in patients with heart disease (P <0.01). Conclusion: Serum levels of MMP-2 in patients with coronary heart disease are significantly increased, and the level of MMP-2 is closely related to the degree of coronary artery stenosis, which may be involved in the occurrence and development of coronary heart disease.