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本实验在ＭＮＮＧ诱发犬胃粘膜癌前病变过程中，胃镜下定期粘膜活检。应用胃癌单克隆抗体ＭＧ７免疫组化染色法及自动化图像分析仪，连续动态定量地监测犬残胃癌前期病变组织中ＭＧ７抗原物质（ＭＧ７－Ａｇ）的表达情况。实验结果表明，①慢性萎缩性胃炎、肠化生及异型增生的组织细胞内已具有胃癌的某些生物学特性。②胃癌前期病变的演变过程可能遵循由萎缩性胃炎→肠化生→异型增生的变化规律。③临床上，重度异型增生患者有很高的癌变率，是由于重度异型增生组织内的某些生物学特性已非常接近于胃癌。
In this experiment, mucosal biopsies were performed under gastroscope during MNNG-induced dog gastric precancerous lesions. The expression of MG7 antigen (MG7-Ag) in canine precancerous lesions of canine was continuously and quantitatively monitored by immunohistochemical staining of gastric carcinoma monoclonal antibody MG7 and automated image analyzer. The experimental results showed that 1 the tissue of chronic atrophic gastritis, intestinal metaplasia, and dysplasia has certain biological characteristics of gastric cancer. 2 The evolution of precancerous lesions may follow the law of atrophic gastritis, intestinal metaplasia, and dysplasia. 3 Clinically, patients with severe dysplasia have a high rate of cancer, which is due to the fact that certain biological characteristics within severe dysplasia are very close to that of gastric cancer.