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目的:探讨徒手复苏和心肺复苏仪对心搏骤停患者心脑缺血性损伤的影响。方法 :以广东省佛山市第一人民医院急诊科2012年1月至2016年1月收治的心搏骤停患者90例为研究对象,并将其随机分为对照组和研究组各45例,在常规对症治疗基础上,对照组按标准徒手心肺复苏方法进行心肺复苏,研究组采用心肺复苏仪进行心肺复苏,比较两组自主循环恢复(ROSC)后及ROSC24h后血液的神经元特异性烯醇化酶(NSE)、血清S100蛋白质、血清肌钙蛋白I(cTnI)、血清心型脂肪酸结合蛋白(H-FABP)指标。结果:两组患者ROSC后的NSE、S100、cTnI及H-FABP水平均显著高于同期健康组(P<0.01),研究组ROSC后24h的NSE、S100、cTnI及H-FABP水平均明显低于对照组(P<0.05)。结论 :心肺复苏仪能够确保持续、有力和迅速按压,从而有效减轻和缓解患者的心脑缺血性损伤,有助于促进患者康复。
Objective: To investigate the impact of free hand resuscitation and cardiopulmonary resuscitation on patients with cardiac arrest after cardiac arrest. Methods: Totally 90 patients with cardiac arrest who were admitted to Emergency Department of First People ’s Hospital of Foshan City, Guangdong Province from January 2012 to January 2016 were selected and divided into control group and study group (n = 45) On the basis of routine symptomatic treatment, CPR was performed in the control group according to the standard freehand CPR method. The CPR group was used for cardiopulmonary resuscitation (CPR). After the spontaneous circulation recovery (ROSC) and the neuron-specific enolase Enzyme (NSE), serum S100 protein, serum troponin I (cTnI) and serum cardiotype fatty acid binding protein (H-FABP). Results: The levels of NSE, S100, cTnI and H-FABP after ROSC were significantly higher in both groups than those in the same period (P <0.01). The levels of NSE, S100, cTnI and H-FABP in ROSC were significantly lower In the control group (P <0.05). Conclusion: CPR can ensure sustained, powerful and rapid compression, which can effectively reduce and alleviate the patient’s ischemic injury and help to promote the rehabilitation of patients.