Hart 等报告由噻丙吩(suprofen)引起轻度可逆性肾功能衰竭(肾衰)综合征,但病原机制未确定。本文报告1例噻丙吩有关的变态反应性间质性肾炎。患者27岁:白人男性,背及胁轻度钝痛、尿痛、尿呈茶色及寒战已有1年。其医疗史包括6年前双下肢粉碎性损伤,每天需服阿司匹林、acetominophen及可待因。入院前24～36h 患者因骨骼肌痛而采用2剂噻丙吩。体检示体温37.3℃;两胁触疹有疼痛。 Hart et al reported mild reversible renal failure (renal failure) syndrome caused by suprofen, but the pathogenic mechanism was not established. This article reports 1 case of thiophene-related allergic interstitial nephritis. Patient 27 years old: Caucasian males, back and mild mild dull pain, dysuria, brown urine and chills have been for 1 year. Its medical history includes comminuted damage to both lower extremities 6 years ago and aspirin, acetominophen and codeine daily. 24 ~ 36h before admission, patients with skeletal muscle pain and two doses of thiophene. Physical examination showed body temperature 37.3 ℃; two threatened with rash pain.