胃癌发病率和死亡率在我国恶性肿瘤中居首位。胃癌病因目前还不十分清楚,外界因素尤其是饮食因素与胃癌发生关系最为密切,但对宿主内在体质因素的研究亦日益受到重视。胃癌发病男性明显高于女性。本文拟对胃癌发病在人群中的性别差异、性激素对实验性胃癌的影响及其在胃癌发生中的作用进行探讨。 The incidence and mortality of gastric cancer rank first in China for malignant tumors. The cause of gastric cancer is still unclear. External factors, especially dietary factors, are most closely related to the occurrence of gastric cancer. However, research on the host internal physical factors has also received increasing attention. The incidence of gastric cancer was significantly higher in men than in women. This article discusses the gender differences in the incidence of gastric cancer in the population, the effect of sex hormones on experimental gastric cancer and its role in the development of gastric cancer.