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目的比较氨氯地平与贝那普利在高血压脑卒中二级预防中的应用效果。方法选取2010年9月—2012年9月湘潭市中心医院收治的高血压脑卒中患者80例,随机分为对照组与观察组,各40例。对照组患者予以贝那普利治疗,观察组患者予以氨氯地平治疗。观察两组患者出院后12、24、36个月的血压〔收缩(SBP)、舒张压(DBP)〕、脑卒中复发情况、心肌梗死及不良反应发生情况。结果 SBP、DBP时间与方法间无交互作用(P>0.05),时间间比较,差异无统计学意义(P>0.05),组间比较,差异无统计学意义(P>0.05),出院后12、24、36个月两组患者SBP、DBP比较,差异无统计学意义(P>0.05);观察组患者脑卒中复发率低于对照组,差异有统计学意义(P<0.05);两组患者心肌梗死发生率比较,差异无统计学意义(P>0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论氨氯地平与贝那普利在高血压脑卒中二级预防中的应用效果相当,氨氯地平可降低脑卒中复发率。
Objective To compare the effect of amlodipine and benazepril in secondary prevention of stroke complicated by hypertension. Methods Eighty patients with hypertensive stroke admitted in Xiangtan Central Hospital from September 2010 to September 2012 were randomly divided into control group and observation group, 40 cases in each group. Patients in the control group were treated with benazepril, and patients in the observation group were treated with amlodipine. The blood pressure (systolic pressure (SBP), diastolic blood pressure (DBP)), recurrent stroke, myocardial infarction and adverse reactions were observed at 12, 24 and 36 months after discharge. Results There was no interaction between SBP and DBP time (P> 0.05). There was no significant difference in time between two groups (P> 0.05). There was no significant difference between two groups (P> 0.05) (P> 0.05). The recurrent rate of stroke in the observation group was lower than that in the control group (P <0.05), and the difference was statistically significant (P <0.05) between the two groups The incidence of myocardial infarction in patients with no significant difference (P> 0.05); two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Amlodipine and benazepril are effective in secondary prevention of hypertension stroke, and amlodipine can reduce the recurrence rate of stroke.