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200965 肝细胞生长刺激物质(HSS)介导阿霉素对人肝癌细胞裸鼠移植瘤的作用及其对c-met癌基因的影响/杨秀疆…//实用肿瘤杂志.-1999,14(6).-333～335 裸鼠移植瘤腹腔内注射化疗药物及HSS 2周,病理学及免疫组化法检查C-met癌基因。结果:中剂量阿霉索(ADM)(0.25μg/gbw)联合HSS抑瘤率达72%,单用大剂量ADM(0.50μg/gbw)无明显作用,但不良反应明显,单用HSS无抑瘤及刺激增生作用。裸鼠移植瘤组织表达C-met癌基因,HSS单用组对C-met影响不大,中剂量联合组C-met表达明显。认为:HSS介导中剂量ADM的抑瘤效用可能与影响C-met的表达有关。中剂量联合方法疗效较高,既
200965 Effects of Hepatocyte Growth Stimulating Substance (HSS) Mediated by Adriamycin on Human Hepatocarcinoma Cells in Nude Mice Transplantation Tumor and Its Effect on c-met Oncogene/Yang Xiu-Ge... //practical Oncology.-1999,14(6) .-333 ~ 335 Nude mice transplanted with intraperitoneal injection of chemotherapeutic drugs and HSS for 2 weeks, pathological and immunohistochemical examination of C-met oncogene. RESULTS: The inhibitory rate of mid-dose ADM (0.25 μg/gbw) combined with HSS was 72%, and no significant effect was observed with high-dose ADM alone (0.50 μg/gbw), but the adverse reactions were obvious. Tumor and stimulate proliferation. The expression of C-met oncogene was observed in xenografts of nude mice. The HSS alone group had little effect on C-met, and the C-met expression was significant in the combined dose group. It is believed that the inhibitory effect of HSS mediating mid-dose ADM may be related to the influence of C-met expression. The combination of medium-dose methods has a high efficacy, both