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5只不麻醉正常狗的肾血浆流量(对氨基马尿酸清除率)和肾小球滤过率(肌酐清除率)分别为160(毫升/分)和44(毫升/分)。2只神经原型高血压狗肾血浆流量和肾小球滤过率分别为144和63。3只肾型高血压狗肾血浆流量和肾小球滤过率分别为110和44。神经原型狗或肾型狗的肾血浆流量,肾小球滤过率,肾血流量和肾小球滤过部分与正常狗相应比较时,并无显著差异。5只不麻醉正常狗静脉注射萝芙木碱0.2—1毫克/公斤后,在血压骤降期间内,肾小球滤过率及肾血浆流量等也都明显下降,在血压复原后1小时内肾小球滤过率增加,肾血浆流量降低。5只高血压狗每天口服萝芙木碱2—8毫克/公斤共10天,于血压显著下降后肾血浆流量(5只)和肾小球滤过率(3只)明显的增加,血球比容量(5只)则较给药前减低;停药后肾血浆流量,肾小球滤过率及血球比容量均恢复到给药前水平。在给药前后肾血浆流量和肾小球滤过部分无变化。
The renal plasma flow (paraminoclauric acid clearance) and glomerular filtration rate (creatinine clearance) of 5 non-anesthetized normal dogs were 160 (ml / min) and 44 (ml / min), respectively. The plasma flow rate and glomerular filtration rate of two neurogenic hypertensive dogs were 144 and 63.3, respectively. The renal plasma flow and glomerular filtration rate of renal hypertensive rats were 110 and 44, respectively. There was no significant difference in renal plasma flow, glomerular filtration rate, renal blood flow, and glomerular filtration fraction in neurogenic or nephrotic dogs when compared to normal dogs. 5 only anesthetized normal dog intravenous injection of Raloxuca 0.2-1 mg / kg, during the sudden drop in blood pressure, glomerular filtration rate and renal plasma flow were also significantly decreased within 1 hour after the recovery of blood pressure Glomerular filtration rate increased, renal plasma flow decreased. Five hypertensive dogs were orally given rapamycin 2-8 mg / kg orally daily for 10 days. After the blood pressure dropped significantly, the renal plasma flow (5) and glomerular filtration rate (3) increased significantly. The blood ratio Volume (5) was lower than before treatment; after stopping the renal plasma flow, glomerular filtration rate and hematocrit were restored to pre-dose levels. There was no change in renal plasma flow and glomerular filtration before and after administration.