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流行病学研究和动物实验揭示了某些食物在预防癌症中的有益作用。化学预防的临床试验期望使补充这些物质的受试者癌症发生率下降。某些研究集中在有癌前病变或有癌病史的高危个体。另一些则选择了原发癌症的化学预防研究。这些初步预防试验很适合于研究对某一种疾病或器官系统可能有益的化学物质。由于研究需要非常大的样本及很长的试验周期,进行试验的后勤问题是很值得重视的。
Epidemiological studies and animal experiments have revealed the beneficial effects of certain foods in the prevention of cancer. Clinical trials of chemoprevention are expected to reduce the incidence of cancer in subjects who supplement these substances. Some studies have focused on high-risk individuals with a precancerous lesion or a history of cancer. Others chose chemoprevention studies of primary cancers. These preliminary prevention trials are well suited to study chemicals that may be beneficial to a disease or organ system. Because the study requires very large samples and a long test period, the logistical problems of the tests are worth paying attention to.