纤维蛋白溶酶原激活物(PA)及其受体(PAR)的基因表达与肿瘤的生长、浸润有关。在肝细胞癌和其它肝病中PA的基因表达尚无资料,有关这类病人血浆uPA、tPA水平的报告也不能说明肝脏是血浆PA的组织来源。作者采用RT-PCR方法,研究了肝癌组织、癌周组织和非肿瘤肝脏组织中uPA、uPAR、tPA的基因表达,并比较癌组织和癌周组织不同基因表达水平 The gene expression of plasminogen activator (PA) and its receptor (PAR) is related to tumor growth and infiltration. There is no data on the gene expression of PA in hepatocellular carcinoma and other hepatic diseases. Reports on plasma uPA and tPA levels in these patients cannot explain whether liver is the tissue source of plasma PA. The authors used RT-PCR to study the gene expression of uPA, uPAR, and tPA in hepatocellular carcinoma tissues, pericancerous tissues, and non-tumor liver tissues, and to compare the expression levels of different genes in cancer tissues and tissues.