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TH 细胞在超敏反应性疾病所致迟发生炎症反应的发病机制中占重要地位。 IFN-γ是 TH1细胞的主要效应因子 ,其局部浓度的改变直接影响炎症反应的程度。研究发现 ,传统免疫治疗即是通过提高致敏局部 IFN- γ分泌而获得成功。在现代免疫治疗中 ,人们亦已尝试直接应用 IFN- γ治疗超敏反应性疾病并取得了一定的临床效果。为使 IFN-γ在局部持久而稳定的表达 ,有人用质粒运载IFN- γ基因至炎症局部 ,在动物实验中获得满意结果。 IFN- γ应用于临床的实用性、安全性有待更广泛的研究。
TH cells play an important role in the pathogenesis of delayed inflammatory response induced by hypersensitivity diseases. IFN-γ is the main effector of TH1 cells, the local concentration of IFN-γ directly affects the degree of inflammatory response. The study found that traditional immunotherapy that is by enhancing the sensitized local IFN-γ secretion and success. In modern immunotherapy, people have also tried to directly apply IFN-γ for the treatment of hypersensitivity diseases and have achieved some clinical effects. In order to make IFN-γ in local, long-lasting and stable expression, some people carry the IFN-γ gene by plasmids to the inflammation site, and get satisfactory results in animal experiments. The application of IFN-γ in clinical practice, safety needs to be more extensively studied.