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目的:研究了文拉法辛(venlafaxine,VEN)在乙炔黑-离子液体复合修饰玻碳电极(acetylene black-ionic liquid modifiedglassy carbon electrode,AB-ILs/GCE)上的电化学行为及电化学动力学性质,据此建立了VEN电化学定量测定方法。方法:采用循环伏安法(cyclic voltammetry,CV),计时电流法(chronoamperometry,CA),计时电量法(chronocoulometry,CC),方波伏安法(square wave voltammetry,SWV)及电化学阻抗谱(EIS)等电化学方法。结果:VEN在玻碳电极(GCE)上于0.91 V处出现一不可逆氧化峰,与GCE相比VEN在AB/GCE上的氧化峰电位负移150 mV,氧化峰电流增大4倍;而与AB/GCE相比VEN在AB-ILs/GCE上的氧化峰电位基本不变,氧化峰电流增大1.6倍。同时考察了实验条件对VEN伏安行为影响,测定了电极反应过程动力学参数,并用本方法对VEN胶囊中VEN含量进行了定量测定,RSD在1.7%～2.5%之间,加标回收率在96.30%～102.2%之间。结论:AB-ILs/GCE对VEN电化学氧化有明显的催化作用,是一受扩散控制的不可逆电极过程,该方法可用于市售VEN胶囊中VEN含量的电化学定量测定。
OBJECTIVE: To study the electrochemical behavior and electrochemical kinetics of venlafaxine (VEN) on acetylene black-ionic liquid modified glassy carbon electrode (AB-ILs / GCE) Nature, thus establishing a VEN electrochemical quantitative determination method. Methods: Cyclic voltammetry (CV), chronoamperometry (CA), chronocoulometry (CC), square wave voltammetry (SWV) and electrochemical impedance spectroscopy EIS) and other electrochemical methods. Results: VEN showed an irreversible oxidation peak at 0.91 V at the glassy carbon electrode (GCE). Compared with GCE, VEN exhibited a negative shift of 150 mV in oxidation peak potential at AB / GCE and a 4-fold increase in oxidation peak current. Compared with VEN, the oxidation peak potential of AB-ILs / GCE in AB / GCE remained unchanged, and the oxidation peak current increased by 1.6 times. At the same time, the influence of the experimental conditions on the VEN voltammetry behavior was investigated. The kinetic parameters of the electrode reaction process were determined. The VEN content in VEN capsules was determined by this method. The RSD was between 1.7% and 2.5% 96.30% ~ 102.2% between. CONCLUSION: AB-ILs / GCE has obvious catalytic effect on VEN electrochemical oxidation. It is a diffusion-controlled irreversible electrode process. This method can be used for the electrochemical quantitative determination of VEN in commercially available VEN capsules.