目的分析４例少见部位骨肉瘤临床及Ｘ线表现。方法收集我院经病理证实的病例，对其临床表现、发病部位及Ｘ线特征进行分析，并结合文献进行讨论。结果发生于锁骨骨干１例，肩峰及下颌骨各１例，多发性骨肉瘤１例，共６个部位，每例均具有较为特殊的临床及Ｘ线表现。结论骨肉瘤好发于四肢长骨干骺端，亦可发生于短骨、扁骨及不规则骨；病灶多为单发，亦可为多发。 Objective To analyze the clinical and X-ray findings of 4 rare osteosarcoma sites. Methods We collected the cases confirmed by pathology in our hospital, analyzed their clinical manifestations, pathological locations and X-ray features, and discussed the literature. The results occurred in 1 case of the clavicle, 1 case of acromion and mandible, and 1 case of multiple osteosarcoma, totaling 6 sites. Each case had a special clinical and X-ray findings. Conclusion Osteosarcoma occurs predominantly in the metaphyseal limbs of long limbs. It can also occur in short bones, flat bones, and irregular bones. The lesions are mostly single or multiple.