很久以来人们对精氨酸酶活性的认识仅局限于哺乳动物的肝脏.认为它主要参与尿素的生成.目前认为精氨酸酶可由活化的巨噬细胞(Mφ)分泌,并作为其活性介质之一直接在免疫应答中起作用.实验表明(1)在混合淋巴细胞培养中(MLC)如加入Mφ,可抑制细胞毒T细胞的产生,同时培养基中精氨酸酶活性逐渐升高,该作用可因向MLC中加入精氨酸或预先去除Mφ而逆 It has long been known that arginase activity is limited to the liver of mammals and is believed to be mainly involved in the production of urea It is presently believed that arginase is secreted by activated macrophages (Mφ) and serves as an active mediator Has been directly in the immune response to play a role.The experiment showed that (1) in mixed lymphocyte culture (MLC) such as adding Mφ can inhibit the production of cytotoxic T cells, while the arginase activity in the medium gradually increased, the The role of MLC can be added due to arginine or anti-Mφ in advance