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目的 :探讨米非司酮对胎脑组织超微结构的影响。方法 :将具有终止妊娠指征的健康中孕妇女随机分为米非司酮组与对照组 ,每组各 5例 ,孕周为 1 8～ 2 1周。米非司酮组在水囊引产前 6h服用 1 50mg米非司酮 ,对照组只行水囊引产。结果 :与对照组相比 ,米非司酮组的胎脑组织可见 :(1 )神经细胞染色质分布不均 ,常呈块状 ,浓缩或边聚现象常见 ;(2 )神经细胞核周质内细胞器肿胀或缺如 ,核糖体稀疏 ,微丝及微管少见 ;(3 )暗细胞增多 ;(4 )神经纤维肿胀 ,所含微丝及微管排列紊乱 ;(5)血管外围的星形胶质细胞脚板明显肿胀。结论 :米非司酮可造成胎脑组织缺氧性损伤。由于足月新生儿的神经细胞已基本成熟不可再生 ,认为在米非司酮对胎儿的安全性未充分论证前 ,不宜用于足月妊娠的引产
Objective: To investigate the effect of mifepristone on the ultrastructure of fetal brain tissue. Methods: Healthy pregnant women with indications of termination of pregnancy were randomly divided into mifepristone group and control group, 5 cases in each group, gestational age was 18 to 21 weeks. The mifepristone group took 150 mg of mifepristone 6 hours before induction of labor and the control group only induced abortion. Results: Compared with the control group, fetal brain tissue in the mifepristone group showed: (1) uneven distribution of chromatin in nerve cells, often massive, condensed or edge aggregation phenomenon; (2) within the nucleus of the neurons Organelles are swollen or absent, sparse ribosomes, rare microfilaments and microtubules; (3) dark cells increase; (4) swelling of nerve fibers, disordered arrangement of microfilaments and microtubules; (5) astrocytes Tailings of the somatic cells were markedly swollen. Conclusion: Mifepristone can cause hypoxic injury of fetal brain tissue. As full-term neonatal nerve cells have been basically non-renewable, that the safety of mifepristone on the fetus is not fully demonstrated before, should not be used for full-term pregnancy induction