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目的:观察益气活血法联合α-硫辛酸治疗痛性糖尿病周围神经病变(PDPN)的临床疗效。方法:将60例PDPN患者随机分为治疗组和对照组各30例,对照组单用西医常规治疗,治疗组在对照组治疗基础上加用益气活血中药结合α-硫辛酸治疗,2组疗程均为4周。比较治疗前后糖化血红蛋白(HBA1c)及多伦多临床评分(TCSS)。结果:总有效率治疗组为96.67%,对照组为80.00%,2组比较,差异有统计学意义(P<0.05);2组HBAlc和TCSS评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.01或P<0.05)。结论:益气活血法联合α-硫辛酸治疗PDPN有良好的临床疗效。
Objective: To observe the clinical efficacy of Yiqi Huoxue combined with α-lipoic acid in the treatment of painful diabetic peripheral neuropathy (PDPN). Methods: Sixty patients with PDPN were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was treated with conventional Western medicine only. The treatment group was treated with Yiqi Huoxue medicine combined with α-lipoic acid on the basis of the control group. All for 4 weeks. Pre and post-treatment glycosylated hemoglobin (HBA1c) and Toronto clinical score (TCSS) were compared. Results: The total effective rate was 96.67% in the treatment group and 80.00% in the control group. There was significant difference between the two groups (P <0.05). The levels of HBAlc and TCSS in the two groups before and after treatment were significantly higher than those in the control group The differences were statistically significant (P <0.01 or P <0.05). Conclusion: Yiqihuoxue combined with α-lipoic acid in the treatment of PDPN has a good clinical effect.