论文部分内容阅读
目的评估不同血糖控制情况下T2DM患者甲状腺功能对血脂代谢的影响。方法选取住院T2DM患者595例,根据HbA1c水平分为HbA1c<7.0%组108例、7.0%≤HbA1c<9.0%组164例及HbA1c≥9.0%组323例,另选取健康体检者61名作为对照(NC)组。对各组指标进行比较,明确T2DM患者甲状腺功能指标与非高密度脂蛋白胆固醇(non-HDL-C)的关系。结果 HbA1c≥9.0%组non-HDL-C水平高于HbA1c<7.0%组、7.0%≤HbA1c<9.0%组和NC组[(3.84±1.16)vs(3.32±1.07),(3.59±0.96),(3.21±0.77)mmol/L,P均<0.05]。HbA1c≥9.0%组游离三碘甲状腺原氨酸(FT3)水平低于HbA1c<7.0%组、7.0%≤HbA1c<9.0%组和NC组[(2.43±0.50)vs(2.69±0.46),(2.66±0.45),(2.91±0.44)pg/ml,P均<0.05]。T2DM患者non-HDL-C与BMI、FPG和HbA1c呈正相关,与FT3呈负相关。多元线性回归分析提示,BMI、HbA1c和FT3是non-HDL-C的影响因素。结论随血糖升高,T2DM患者血脂代谢紊乱加重,FT3水平下降;FT3是影响T2DM患者血脂变化的重要因素。
Objective To evaluate the effect of thyroid function on blood lipid metabolism in patients with T2DM under different glycemic control. Methods According to the level of HbA1c, there were 595 inpatients with T2DM. According to the HbA1c level, there were 108 cases with HbA1c <7.0%, 164 cases with 7.0% ≤HbA1c <9.0% and 323 cases with HbA1c≥9.0%, and 61 healthy subjects were selected as control NC) group. The indicators of each group were compared to determine the relationship between thyroid function and non-HDL-C in patients with T2DM. Results The level of non-HDL-C in HbA1c≥9.0% group was significantly higher than that in HbA1c <7.0%, 7.0% ≤HbA1c <9.0% and NC group (3.84 ± 1.16 vs 3.32 ± 1.07, 3.59 ± 0.96, (3.21 ± 0.77) mmol / L, P <0.05]. The level of free triiodothyronine (FT3) in HbA1c≥9.0% group was lower than that in HbA1c <7.0%, 7.0% ≤HbA1c <9.0% and NC group (2.43 ± 0.50 vs 2.69 ± 0.46, 2.66 ± 0.45), (2.91 ± 0.44) pg / ml, all P <0.05]. Non-HDL-C in T2DM patients was positively correlated with BMI, FPG and HbA1c, but negatively correlated with FT3. Multiple linear regression analysis suggested that BMI, HbA1c and FT3 were the influencing factors of non-HDL-C. Conclusion With the increase of blood glucose, the disturbance of blood lipid metabolism and the level of FT3 decrease in T2DM patients. FT3 is an important factor affecting the blood lipid level in T2DM patients.