儿童慢性乙型肝炎(CHB)可进展至严重的肝脏损害,包括肝硬化、肝衰竭,甚至肝癌[1-2]。亚太大部分地区,尤其在我国90%以上的成人CHB源于儿童期感染。因此儿童CHB的抗病毒治疗越来越受到关注,有效的抗病毒治疗能够阻止肝脏疾病的活动性进展,从而降低成人活动进展型肝病和晚期重症肝病的发生率[3-4]。 Children with chronic hepatitis B (CHB) can progress to severe liver damage, including cirrhosis, liver failure, and even liver cancer [1-2]. CHB in more than 90% of adults in most parts of Asia and the Pacific stems from childhood infection. Therefore, children’s CHB antiviral treatment more and more attention, effective antiviral therapy can prevent the progress of liver disease activity, thereby reducing the progress of adult active advanced liver disease and advanced severe liver disease [3-4].